Njei’s research program is highly interdisciplinary, bridging hepatology, cardiology, data science, and global health. His scientific contributions can be consolidated into the following thematic areas: 1. Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD/NAFLD) and Advanced Fibrosis Development of FibroX, a machine-learning model for detecting and prognosticating advanced fibrosis in MASLD. Explainable machine learning models for prediction of high-risk nonalcoholic steatohepatitis (Scientific Reports, 2024). Diagnosis and management of lean MASLD: a systematic review. AI-based screening for at-risk MASLD and advanced fibrosis in the U.S. population. Validation of AI tools for improving MASLD advanced liver fibrosis diagnosis in primary care. Mortality, hepatic decompensation, and cardiovascular outcomes in lean vs. non-lean MASLD cirrhosis. 2. Hepatocellular Carcinoma (HCC) and Liver Cancer Epidemiology Emerging trends in hepatocellular carcinoma incidence and mortality (Hepatology, 2015). Prognosis of fibrolamellar HCC versus conventional HCC: a systematic review and meta-analysis (Gastrointestinal Cancer Research, 2014). Survival after curative-intent treatment for HCC among patients with vs. without non-alcoholic fatty liver disease (Alimentary Pharmacology & Therapeutics, 2017). Cancer disparities in lean vs. non-lean MASH: insights from a national inpatient sample. The association between metabolic syndrome and primary liver cancer: a meta-analysis. 3. Artificial Intelligence and Digital Health in Hepatology Large language models for diagnosis and prognosis of chronic liver diseases: a systematic review. Artificial intelligence in medical imaging for cholangiocarcinoma diagnosis. AI-enabled electrocardiography for risk prediction in chronic liver disease: a systematic review. FibroAgent: an agentic AI tool for liver fibrosis screening and clinical decision support in MASLD. Using large language models to predict advanced liver fibrosis in MASLD: a proof-of-concept analysis. Digital twins in hepatology and gastroenterology: a scoping review. 4. Cardiovascular–Liver (Cardio-Hepatology) Interactions Liver fibrosis and cardiovascular events (Southern Medical Journal, 2025). Effects of hypercholesterolemia and statin exposure on survival in a large national cohort of patients with cirrhosis. The association between hepatitis C infection and cardiovascular disease: a meta-analysis of epidemiologic evidence. 5. Cirrhosis, Chronic Liver Disease, and Global Hepatology The burden of cirrhosis and other chronic liver disease in the Middle East and North Africa (MENA) region over three decades (BMC Public Health, 2024). Socioeconomic and demographic disparities in the impact of digestive diseases in the MENA region. Treatment and prevention of viral hepatitis in pregnancy. Changing epidemiology of hepatitis C virus infection in the United States: NHANES 2001–2010 (Journal of Hepatology, 2013). 6. Endoscopy, Biliary Disease, and Pancreatology Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures: a systematic review and meta-analysis. Endoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures: a systematic review and meta-analysis. Pancreatic stent placement for prevention of post-ERCP pancreatitis: a network meta-analysis. 7. Gastroenterology and General Hepatology Prevalence, trends, and risk factors for fecal incontinence in U.S. adults, 2005–2010 (Clinical Gastroenterology and Hepatology, 2013). Vanishing bile duct syndrome associated with Hodgkin’s lymphoma: case report and literature review. Endotoxin down-regulates type 3 inositol 1,4,5-trisphosphate receptor in human cholangiocytes (Hepatology, 2019). SELECTED HONORS AND FELLOWSHIPS
Fellow, Royal College of Physicians (FRCP), 2025 Dame Sheila Sherlock Travelling Fellowship in Hepatology, University of Oxford, 2026 Fulbright Specialist, Visiting Professor of Global Health, 2025 Fellow, American College of Health Data Management, 2024 Member, Wolfson College, Oxford, 2026 Member, Peer Review Committee, Canadian Institutes of Health Research, 2026 Member, Global Outreach and Engagement Committee, AASLD, 2026 Editorial Staff, JAMA, 2026 Associate Editor, Clinical Medicine (Royal College of Physicians), 2026 Associate Editor, Pan African Medical Journal, 2025 Guest Editor, Livers (MDPI) – Special Issue on chronic liver disease and cirrhosis, 2025 Guest Editor, BMC Global and Public Health, 2026